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Abstract #3261

Potential for Polarization Measurement of Pre-Polarized [1-13C] Pyruvate in Vivo Using Jcc Spectral Pattern

Albert P. Chen1, Charles H. Cunningham2, James Tropp3, Kayvan Keshari4, Mark VanCriekinge4, John Kurhanewicz4, Ralph E. Hurd5

1GE Healthcare, Toronto, ON, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3GE Healthcare, Fremont, CA, United States; 4Radiology, UCSF, San Francisco, CA, United States; 5GE Healthcare, Menlo Park, CA, United States

The ability to accurately measure or predict the polarization of hyperpolarized 13C metabolic imaging substrates at the time of the MR experiment is necessary for quantitative kinetics data or metabolite concentrations. In this study, the feasibility of using asymmetry of the pyruvate C2 resonance (from 1% natural abundance of [1,2-13C2] pyruvate) to estimate the polarization of the [1-13C] pyruvate in vivo is demonstrated.