Abstract #3261

Potential for Polarization Measurement of Pre-Polarized [1-13C] Pyruvate in Vivo Using Jcc Spectral Pattern

Albert P. Chen¹, Charles H. Cunningham², James Tropp³, Kayvan Keshari⁴, Mark VanCriekinge⁴, John Kurhanewicz⁴, Ralph E. Hurd⁵

¹GE Healthcare, Toronto, ON, Canada; ²Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; ³GE Healthcare, Fremont, CA, United States; ⁴Radiology, UCSF, San Francisco, CA, United States; ⁵GE Healthcare, Menlo Park, CA, United States

The ability to accurately measure or predict the polarization of hyperpolarized 13C metabolic imaging substrates at the time of the MR experiment is necessary for quantitative kinetics data or metabolite concentrations. In this study, the feasibility of using asymmetry of the pyruvate C2 resonance (from 1% natural abundance of [1,2-¹³C₂] pyruvate) to estimate the polarization of the [1-¹³C] pyruvate in vivo is demonstrated.