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Abstract #3262

Non-Fourier Spatial Encoding for Improved Point-Spread-Functions in Hyperpolarized 13C CSI Acquisitions

Albert P. Chen1, Ralph E. Hurd2, Charles H. Cunningham3,4

1GE Healthcare, Toronto, ON, Canada; 2GE Healthcare, Menlo Park, CA, United States; 3Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 4Medical Biophysics, University of Toronto, Toronto, ON, Canada

Metabolic imaging using pre-polarized substrates labeled with a 13C nucleus has proven to be a promising new tool. Often, chemical-shift imaging (CSI) acquisitions are used to map the 13C resonances over 2D or 3D volumes so that 13C metabolic data from various tissues can be compared. Due to the time constraints imposed by the relatively short lifetime of the hyperpolarized state, the spatial dimensions of these acquisitions are often encoded with small matrix sizes (e.g. 8 x 8 x 16), resulting in a relatively poor point-spread function (PSF). In this abstract, we have explored the use of non-Fourier spatial encoding to improve the PSF in both in-plane dimensions of hyperpolarized 13C CSI acquisitions. Phantom experiments showed an improved point-spread function and a rat study showed the feasibility of using the method for in vivo data acquisition.