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Abstract #3263

The Effects of Contrast Agents on Hyperpolarised [1-13C]-Pyruvic Acid

Lanette Friesen Waldner1,2, Timothy Scholl3, Albert Chen4, Brian Rutt, 1,5, Charles McKenzie, 12

1Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada; 2Medical Biophysics, The University of Western Ontario, London, ON, Canada; 3Physics and Astronomy, The University of Western Ontario, London, ON, Canada; 4GE Healthcare, Toronto, ON, Canada; 5Diagnostic Radiology and Richard M Lucas Center for Imaging, Stanford University, Stanford, CA, United States

The addition of small quantities of gadolinium based contrast agents (GBCA) to 13C-enriched samples containing trityl radical significantly increases the hyperpolarisation that can be obtained via dynamic nuclear polarisation. This study examined the effects of several contrast agents on T1 in solution and on relative hyperpolarisation in the solid state in [1-13C]-labeled pyruvic acid. T1 decreased with increasing contrast agent concentration with all contrast agents except Teslascan. Dotarem and ProHance showed a slight decrease in T1. MultiHance showed the largest increase in hyperpolarisation and the largest decrease in T1. The choice of contrast agent may depend on the application.