Mette Hauge Lauritzen1, Peter Magnusson1,
Sadia Asghar Butt1, Jan Henrik Ardenkjr-Larsen2, Lise
Vejby Sgaard1, Per keson1
1Danish Research Centre for Magnetic
Resonance, Copenhagen University Hospital, Hvidovre, Denmark; 2GE
Health Care, Hillerd, Denmark
Magnetic
resonance spectroscopy (MRS) using hyperpolarized 13C[pyruvate] was tested in
a experimental rat model of acute myocardial infarction. MRS-images and
dynamic time series was acquired before and after infarction to evaluate
metabolic changes in the myocardium. After infarction the signal from
lactate, alanine, and bicarbonate were absent in the infarcted region,
whereas, in the region not affected by infarction, the signal levels were
comparable to the levels in the MRS-images acquired before infarction. This
study demonstrates that hyperpolarized 13C MRS can be used to visualize
regional changes in cardiac metabolism in rats after myocardial infarction.
Keywords