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Abstract #3270

Visualizing Regional Changes in Metabolism in a Rat Model of Acute Myocardial Infarction Using Hyperpolarized 13C MR

Mette Hauge Lauritzen1, Peter Magnusson1, Sadia Asghar Butt1, Jan Henrik Ardenkjr-Larsen2, Lise Vejby Sgaard1, Per keson1

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark; 2GE Health Care, Hillerd, Denmark

Magnetic resonance spectroscopy (MRS) using hyperpolarized 13C[pyruvate] was tested in a experimental rat model of acute myocardial infarction. MRS-images and dynamic time series was acquired before and after infarction to evaluate metabolic changes in the myocardium. After infarction the signal from lactate, alanine, and bicarbonate were absent in the infarcted region, whereas, in the region not affected by infarction, the signal levels were comparable to the levels in the MRS-images acquired before infarction. This study demonstrates that hyperpolarized 13C MRS can be used to visualize regional changes in cardiac metabolism in rats after myocardial infarction.