Martin
Janich1,2, Eliane Weidl3, Florian Wiesinger4,
Marion I. Menzel4, Jan Henrik Ardenkjaer-Larsen5,
Steffen J. Glaser1, Rolf F. Schulte4, Markus Schwaiger3
1Department of Chemistry, Technische
Universitt Mnchen, Munich, Germany; 2Imaging Technologies, GE
Global Research , Munich, Germany; 3Institute for Nuclear
Medicine, Technische Universitt Mnchen, Munich, Germany; 4Imaging
Technologies, GE Global Research, Munich, Germany; 5MST-ASL MR, GE
Healthcare, Copenhagen,, Denmark
The
aim of this study is to investigate the influence of injected hyperpolarized 13C
pyruvate concentration on its cellular uptake and enzymatic conversion in
rats. A 5 mL/kg rat mass solution was injected at concentration levels of 40
mM and 80 mM hyperpolarized 13C pyruvate. Concentration time
curves of the metabolites pyruvate, lactate, alanine, and bicarbonate were
measured with FID signals in slices through the heart, liver, and kidneys. A
significant dependency of observed metabolite concentrations on injected
pyruvate concentration was recognized in all slices.