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Abstract #3269

Influence of Injected Pyruvate Concentration on Metabolism Using Hyperpolarized 13C

Martin Janich1,2, Eliane Weidl3, Florian Wiesinger4, Marion I. Menzel4, Jan Henrik Ardenkjaer-Larsen5, Steffen J. Glaser1, Rolf F. Schulte4, Markus Schwaiger3

1Department of Chemistry, Technische Universitt Mnchen, Munich, Germany; 2Imaging Technologies, GE Global Research , Munich, Germany; 3Institute for Nuclear Medicine, Technische Universitt Mnchen, Munich, Germany; 4Imaging Technologies, GE Global Research, Munich, Germany; 5MST-ASL MR, GE Healthcare, Copenhagen,, Denmark

The aim of this study is to investigate the influence of injected hyperpolarized 13C pyruvate concentration on its cellular uptake and enzymatic conversion in rats. A 5 mL/kg rat mass solution was injected at concentration levels of 40 mM and 80 mM hyperpolarized 13C pyruvate. Concentration time curves of the metabolites pyruvate, lactate, alanine, and bicarbonate were measured with FID signals in slices through the heart, liver, and kidneys. A significant dependency of observed metabolite concentrations on injected pyruvate concentration was recognized in all slices.