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Abstract #3272

Detection of Early Response to Temozolomide Treatment in Brain Tumors Using Hyperpolarized 13C MR Metabolic Imaging

Ilwoo Park1,2, Myriam Chaumeil2, Tomoko Ozawa3, Sabrina M. Ronen1,2, Daniel B. Vigneron1,2, C. David James3, Sarah J. Nelson1,2

1Joint Graduate group in Bioengineering, University of California San Francisco/Berkeley, San Francisco, CA, United States; 2Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 3Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States


We have demonstrated the feasibility of using DNP hyperpolarized 13C1-pyruvate to detect early response to Temozolomide treatment in an orthotopic human glioblastoma xenograft model in rat brain. The 13C data from the treated rats showed the ability to detect altered tumor metabolism as early as one day after TMZ treatment initiation, while the tumor volume from T1 post-Gd imaging showed the first sign of reduction at the 8th day after the initiation of treatment.

Keywords

treatmenttumor