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Abstract #3281

Cerebral Dynamics and Metabolism of Hyperpolarized [1-13C] Pyruvate Using Time Resolved Spiral-Spectroscopic Imaging

Ralph E. Hurd1, Dirk Mayer2,3, Yi-Fen Yen1, James Tropp1, Adolf Pfefferbaum2,4, Daniel Spielman3

1Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA, United States; 2SRI International; 3Radiology, Stanford; 4Psychiatry and Behavioral Sciences, Stanford


Dynamic hyperpolarized [1-13C]- pyruvate metabolic imaging in normal anesthetized rat brain is demonstrated on a clinical 3T MRI scanner. A 12 s bolus injection of hyperpolarized [1-13C]-pyruvate is imaged at a 3 s temporal resolution using 125 msec spiral spectroscopic images. The observed dynamics are evaluated with respect to cerebral blood volume, flow, transport, and metabolic exchange with the cerebral lactate pool.

Keywords

lactatebrainbloodtransportmetabolicmodelanimalcerebraldynamicbolusindividualinjectedlabeled