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Abstract #3281

Cerebral Dynamics and Metabolism of Hyperpolarized [1-13C] Pyruvate Using Time Resolved Spiral-Spectroscopic Imaging

Ralph E. Hurd1, Dirk Mayer2,3, Yi-Fen Yen1, James Tropp1, Adolf Pfefferbaum2,4, Daniel Spielman3

1Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA, United States; 2SRI International; 3Radiology, Stanford; 4Psychiatry and Behavioral Sciences, Stanford

Dynamic hyperpolarized [1-13C]- pyruvate metabolic imaging in normal anesthetized rat brain is demonstrated on a clinical 3T MRI scanner. A 12 s bolus injection of hyperpolarized [1-13C]-pyruvate is imaged at a 3 s temporal resolution using 125 msec spiral spectroscopic images. The observed dynamics are evaluated with respect to cerebral blood volume, flow, transport, and metabolic exchange with the cerebral lactate pool.