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Abstract #3282

Metabolic Rate Constant Mapping of Hyperpolarized 13C Pyruvate

Florian Wiesinger1, Isabelle Miederer2, Marion I. Menzel1, Eliane Weidl2, Martin Janich1,3, Jan-Henrik Ardenkjaer-Larsen4, Markus Schwaiger2, Rolf F. Schulte1

1Imaging Technologies, GE Global Research, Munich, Germany; 2Institute for Nuclear Medicine, Technical University Munich, Munich, Germany; 3Department of Chemistry, Technical University Munich, Munich, Germany; 4MST-ASL MR, GE Healthcare, Copenhagen, Denmark

In this work, the two-side, kinetic exchange model is applied for hyperpolarized 13C pyruvate in a way such that it does not involve the pyruvate input function. In combination with time-resolved IDEAL spiral CSI, the method is demonstrated to generate spatially-resolved rate constant maps. Ultimately, the method might be particularly useful for the non-invasive localization and characterization of tumors and their response to therapy.