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Abstract #3283

In Vivo Dynamic Cardiac Magnetic Resonance Spectroscopy with Hyperpolarized [2-13C] Pyruvate in Pigs

Albert P. Chen1, Angus Z. Lau2, Wilfred L. Lam2, Nilesh R. Ghugre2, Graham A. Wright2, Charles H. Cunningham2

1GE Healthcare, Toronto, ON, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

It has recently been shown that pre-polarized [2-13C] pyruvate can be used to monitor TCA cycle metabolism in vitro and in vivo in rat hearts. In this study, the feasibility of obtaining dynamic cardiac MR spectroscopic data in vivo using hyperpolarized [2-13C] pyruvate in pigs on a clinical 3T MR system is demonstrated.