In Vivo Dynamic Cardiac Magnetic Resonance Spectroscopy with Hyperpolarized [2-13C] Pyruvate in Pigs

Albert P. Chen¹, Angus Z. Lau², Wilfred L. Lam², Nilesh R. Ghugre², Graham A. Wright², Charles H. Cunningham²

It has recently been shown that pre-polarized [2-¹³C] pyruvate can be used to monitor TCA cycle metabolism in vitro and in vivo in rat hearts. In this study, the feasibility of obtaining dynamic cardiac MR spectroscopic data in vivo using hyperpolarized [2-¹³C] pyruvate in pigs on a clinical 3T MR system is demonstrated.