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Abstract #3285

Hyperpolarized [2-13C] Fructose: A Hemiketal Substrate for in Vivo Metabolic Imaging

Kayvan R. Keshari1, David M. Wilson, Albert P. Chen2, Robert Bok, Peder E.Z. Larson, Simon Hu, Mark Van Criekinge, Jeffrey M. Macdonald3, Daniel B. Vigneron, John Kurhanewicz

1University of California, San Francisco, San Francisco, Ca, United States; 2GE Healthcare; 3University of North Carolina, Chapel Hill

In this study, [2-13C]-fructose was hyperpolarized using the DNP method and shown to have sufficiently long T1s (≈ 14 sec) and polarizations (≈ 12%) for in vivo hyperpolarized 13C MRSI studies. After injection of [2-13C]-fructose in the TRAMP prostate cancer model, the resonance corresponding to the composite β-fructofuranose and β-fructofuranose-6-phosphate was higher in the regions of tumor as compared to the contralateral benign prostate. The hemiketal C2 of fructose demonstrates the first non-carbonyl to be hyperpolarized for use as a metabolic probe, providing the potential to measure changes in carbohydrate metabolism that occur with human disease.