Thomas Trantzschel1, Ute Bommerich2, Joachim Bargon3, Johannes Bernarding1
1Dept. of Biometrics and Medical Informatics, Otto-von-Guericke-University, Magdeburg, Germany; 2Leibniz Institute for Neurobiology, Magdeburg, Germany; 3Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany
The lack of natural background signal in body tissues qualifies fluorinated substrates as excellent reporter molecules for MRI and MRS investigations. As a further advantage many pharmaceuticals contain 19F allowing for detection of pharmacokinetics and metabolism as well as to investigate anatomical and physiological features, e.g. lung volume. However, due to the restricted in vivo substrate concentration the 19F-signals often remain weak. To overcome these restrictions we enhanced the 19F signal via ParaHydrogen Induced Polarization. Additionally, we increased the efficiency of the spin polarization transfer to this nucleus by applying a field cycling procedure which improves the SNR in 19F-MRI.