Florian
Wiesinger1, Marion I. Menzel1, Eliane Weidl2,
Martin Janich1,3, Markus Schwaiger2, Rolf F. Schulte1
1Imaging Technologies, GE Global
Research, Munich, Germany; 2Institute for Nuclear Medicine,
Technical University Munich, Munich, Germany; 3Department of
Chemistry, Technical University Munich, Munich, Germany
Hyperpolarized
[1-13C]pyruvate has demonstrated significant potential for metabolic MR
imaging. In-vivo metabolism converts
pyruvate into a limited number of 13C detectable downstream metabolites
(including lactate, alanine, bicarbonate) with singlet resonant peaks of
known chemical shifts. With an in-vivo
T1 of ~30s, it provides MR detectable signal only for a very limited time
span. The relevant information is
spread over five dimensions including chemical-shift (CS), three spatial
dimensions and time. In this work, echo time shifted,
single-shot spiral encoding is combined with spectrally-preconditioned,
minimum-norm CS inversion (minimum-norm IDEAL spiral CSI) to efficiently
master this encoding challenge.