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Abstract #3290

Minimum-Norm IDEAL Spiral CSI for Efficient Hyperpolarized 13C Metabolic Imaging

Florian Wiesinger1, Marion I. Menzel1, Eliane Weidl2, Martin Janich1,3, Markus Schwaiger2, Rolf F. Schulte1

1Imaging Technologies, GE Global Research, Munich, Germany; 2Institute for Nuclear Medicine, Technical University Munich, Munich, Germany; 3Department of Chemistry, Technical University Munich, Munich, Germany

Hyperpolarized [1-13C]pyruvate has demonstrated significant potential for metabolic MR imaging. In-vivo metabolism converts pyruvate into a limited number of 13C detectable downstream metabolites (including lactate, alanine, bicarbonate) with singlet resonant peaks of known chemical shifts. With an in-vivo T1 of ~30s, it provides MR detectable signal only for a very limited time span. The relevant information is spread over five dimensions including chemical-shift (CS), three spatial dimensions and time. In this work, echo time shifted, single-shot spiral encoding is combined with spectrally-preconditioned, minimum-norm CS inversion (minimum-norm IDEAL spiral CSI) to efficiently master this encoding challenge.