Rolf F. Schulte1, Marion I. Menzel1, Eliane Weidl2, Martin Janich1,3, Markus Schwaiger2, Florian Wiesinger1
1GE Global Research, Munich, Germany; 2Nuclear Medicine, Technische Universitt Mnchen, Munich, Germany; 3Chemistry, Technische Universitt Mnchen, Munich, Germany
Mapping metabolic rate constants is of high physiological relevance, as for instance the metabolic activity is increased in tumours. In this work, spectral-spatial excitation is used to selectively excite, image and crush the downstream metabolites lactate and alanine. A small tip angle selective imaging of the injected [1-13C]pyruvate then gives the necessary reference for turnover images.