Rolf F.
Schulte1, Marion I. Menzel1, Eliane Weidl2,
Martin Janich1,3, Markus Schwaiger2, Florian Wiesinger1
1GE Global Research, Munich, Germany; 2Nuclear
Medicine, Technische Universitt Mnchen, Munich, Germany; 3Chemistry,
Technische Universitt Mnchen, Munich, Germany
Mapping
metabolic rate constants is of high physiological relevance, as for instance
the metabolic activity is increased in tumours. In this work,
spectral-spatial excitation is used to selectively excite, image and crush
the downstream metabolites lactate and alanine. A small tip angle selective
imaging of the injected [1-13C]pyruvate then gives the necessary reference
for turnover images.
Keywords