Julien Valette1,2, Mohamed Ahmed Ghaly2,
Denis Le Bihan2, Franck Lethimonnier2
(DW) spectroscopy is a unique tool for exploring the intracellular
micro-environment in vivo. In living systems, diffusion is generally
anisotropic, since biological membranes may exhibit anisotropic orientation.
In this work, a volume selective DW-sequence is proposed, allowing
single-shot measurement of the trace of the diffusion tensor (which does not
depend on the gradient orientation relative to the cells). Cross-terms
between diffusion gradients and other gradients are cancelled out. In
addition, an adiabatic version (similar to the LASER sequence, with diffusion
gradients) is derived. Proof of concept is performed on anisotropic tissues
by varying tissue orientation and intra-voxel shim.