Ultra High-Resolution Absorption Intermolecular Multiple-Quantum NMR Spectroscopy Without Strong Coupling Artifacts Under Inhomogeneous Fields

Xi Chen¹, Meijin Lin¹, Zhong Chen¹

A pulse sequence termed CT-iDH, which combines intermolecular double-quantum filtered sequence for efficient solvent suppression with a modified constant-time (CT) scheme, is designed to achieve fast acquisition of high-resolution intermolecular zero-quantum coherences (iZQCs) and intermolecular double-quantum coherences (iDQCs) spectra without strong coupling artifacts. Furthermore, double-absorption lineshapes are first realized in 2D intermolecular multi-quantum coherences spectra under inhomogeneous fields through a combination of iZQC and iDQC signals to double the resolution without loss of sensitivity. Experiments were performed to test the feasibility of the new method. The study suggests potential applications for in vivo spectroscopy.