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Abstract #3314

High-Resolution GABA Detection With/without J Decoupling Using 2D Multiple-Quantum Coherence Spectroscopy

Xi Chen1,2, Shaolin Yang1, Laura Rowland2, Yihong Yang1

1Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States; 2Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, United States

A modified 2D multiple-quantum coherence sequence is proposed to achieve high-resolution selective GABA detection under inhomogeneous fields. The edited spectra of GABA with and without J splittings can be obtained from the sequence. Sparse sampling in the indirect dimension is utilized to reduce the entire acquisition time. A phantom experiment was performed to demonstrate the feasibility of the proposed method and its potential applications for in vivo studies.