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Abstract #3333

Regional Difference in Glycine Concentrations in Human Brain as Measured by 1H-MRS at 7T in Vivo

Changho Choi1, Ivan Dimitrov1,2, Deborah Douglas1, Aditya Patel1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Philips Medical Systems, Cleveland, OH, United States

Measurement of glycine (Gly) in the human brain by 1H-MRS at 7T is reported. A point-resolved spectroscopy (PRESS) sequence with subecho times optimized for differentiation between Gly and myo-inositol was applied for measuring the metabolites in the prefrontal and left frontal cortices of a healthy adult brain, which are gray and white matter dominant, respectively. The Gly-to-creatine concentration ratios were observed to be approximately 2-fold higher in prefrontal than in left frontal. This result suggests that Gly may be present predominantly in gray matter compared to white matter.