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Abstract #3334

J Refocused Coherence Transfer Spectroscopic Imaging at 7T

Jullie W. Pan1, Nikolai Avdievich1, Hoby P. Hetherington1

1Yale University School of Medicine, New Haven, CT, United States

The detection of amino acids at ultra high field is enhanced due to improved spectral resolution in comparison to 3T. However, due to J-modulation and T2 losses short spin echo acquisitions are typically used at 7T. Unfortunately, broad macromolecule resonances, visible at short TE, can make accurate detection of the metabolites difficult. J refocused coherence transfer spectroscopy is known to suppress J-modulation of coupled spin systems, thereby allowing longer echo times and suppressing macromolecule contamination. We describe simulation and implementation of a J-refocused transfer sequence for spectroscopic imaging of glutamate and glutamine in the human brain at 7T.