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Abstract #3335

Correction of Cerebral Metabolite Concentrations for Brain Tissue in Proton Spectroscopic Imaging

Kuan-Ting Wu1, Chen-Shuan Huang1, Stefan Posse2,3, Shang-Yueh Tsai1

1Department of Electrical Engineering, Chang Gung University, Tao Yuan, Taiwan; 2Department of Neurology, University of New Mexico School of Medicine, Alberquerque, NM, United States; 3Department of Electrical & Computer Engineering, University of New Mexico , Alberquerque, NM, United States

A processing procedure is proposed to do the tissue type correction for metabolite concentrations on spectroscopic imaging. Tissue segmentation is first done on 3D high resolution T1 images (MPRAGE). Image registration provided by SPM8 software is then applied to generate GM, WM and CSF probability maps at corresponding slice of spectroscopic imaging for the correction of metabolite concentrations. Our results showed that concentration correction can be done well on two segmentation methods and integration of SPM into tissue type correction is useful for future application of MRSI at different locations and slice orientations.