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Abstract #3362

NMR Plasma Profiling of Newborns with Low Weight at Birth

Jose Manuel Morales1, Carmen Ivorra2, Javier Chaves3, Consuelo Garcia-Vicent2, Maria Isabel Torro2, Jose Redon4, Empar Lurbe2, Daniel Monleon3

1Universitat de Valencia, Valencia, Spain; 2Hospital General Universitario de Valencia, Valencia, Spain; 3Fundacion Investigacion Hospital Clinico Valencia, Valencia, Spain; 4Hospital Clinico Universitario de Valencia, Valencia, Spain

Blood pressure is significantly lower in those children with low birth at weight as compared to those in the other groups. In this communication we present a study of blood plasma NMR spectra for detecting the metabolic differences between low and normal weighted newborns. NMR spectra were obtained for plasma from 51 newborns, of which 20 exhibit weight at birth below 2800 g. Metabolic profiling of newborn blood plasma reveals statistically significant differences between low and normal weighted subjects including phenylalanine, citrulline, glutamine, glycerol and glucose. Interestingly, some of these metabolites are present in breast milk.