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Abstract #3370

NMR Spectroscopy Based Study of Physiological Perturbations During Recurrence of Symptoms in Radiation Sickness

Poonam Rana1, Ahmad Raza Khan1, M Memita Devi1, Sunil Pal2, Subash Khushu1

1NMR Research Centre, INMAS, Delhi, India; 2Division and Cyclotron & Radiopharmaceutical Sciences, INMAS, Delhi, India

Regular monitoring of irradiated patient is essential for clinical management during illness phase of radiation sickness. The present study has been designed to explore metabolic perturbation in mice urine after three weeks of irradiation. The results based on urine NMR spectra analysis exhibited an altered energy, amino acid and gut microflora metabolism which could indicate renal and liver dysfunction. These changes could be the consequence of radiation induced damage to physiological systems during recurrence of clinical symptoms after recovery period. The information attained from the study along with biochemical assays could be very useful in assessing the organ dysfunction during radiation sickness.