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Abstract #3380

Reproducibility of ME-COSI in Human Brain and Phantom

Gaurav Verma1, Scott Logan Lipnick2, Nagarajan Rajakumar3, Saad Ramadan4, Michael Albert Thomas3

1Biomedical Engineering, UCLA, Los Angeles, CA, United States; 2Biomedical Physics, UCLA, Los Angeles, CA, United States; 3Radiological Sciences, UCLA, Los Angeles, CA, United States; 4Radiology, Brigham & Women's Hospital, Cambridge, MA, United States

The previously-introduced ME-COSI sequence acquires 2D spectra over a 2D spatial array. ME-COSI reproducibility was investigated in human brain with four volunteers and eight total scans, and in a physiological gray matter phantom with thirty-two scans. Data were post-processed and peak integral/volumes compared to creatine were quantified. Measured coefficients of variation across all scans ranged from 4-17% for single subject in vivo, 7-26% for multiple subjects and 6-25% for in vitro studies, at half the voxel volume. This is comparable to the performance reported from existing single-voxel 2D MRS methods.