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Abstract #3379

Towards a Localized Low Power Adiabatic 2D TOCSY for In-Vivo Use on Clinical Platforms

Ovidiu Cristian Andronesi1, Saadallah Ramadan2, Carolyn E. Mountford2, A Gregory Sorensen1

1Martinos Center for Biomedical Imaging, Radiology Department, Masschusetts General Hospital, Harvard Medical School, Boston, MA, United States; 2Center for clinical spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, United States

Two-dimensional spectroscopy is important for unambiguous assignment of overlapping metabolites and could be more efficient than 1D spectral-editing. 2D TOCSY (TOtal-Correlation-SpectroscopY) is one of the most powerful experiments that reveals the full spin connectivity, but demands for a sustained spin-lock can prevent in-vivo applications. 1D spectral-edited TOCSY was demonstrated recently, although an in-vivo 2D TOCSY has not been realized yet. We propose a modified 2D version of the localized TOCSY, including a z filter and the use of gradient offset independent adiabaticity (GOIA) pulses to reduce SAR. Simulations and phantom measurements on a 3T Siemens MR clinical scanner are presented.