Iosif Alexandru Mendichovszky1, Habib Ashoor2,
David L. Buckley3, Alan Jackson1
1Wolfson Molecular Imaging Centre, The
University of Manchester, Manchester, United Kingdom; 2Physics
Department, University of Bahrain, Bahrain; 3University of Leeds,
Leeds, United Kingdom
The
aims of the study were (1) to investigate the validity of perfusion
measurements for normal and pathological tissues using the upslope method
(USM) in dynamic CT and MR from computer simulations in non-leaky and leaky
capillaries and (2) to explore the effects of SNR and injection rate on the
accuracy of perfusion estimates. The USM can be used to calculate perfusion
in normal and pathological tissues and is most accurate in tissues with
relatively long transit times. Its accuracy can be improved with the use of a
rapid injection (sharp AIF) and is decreased by image noise.
Keywords