Parameter Influence in Dynamic-Contrast-Enhanced MRI Analyses

Xin Li¹, William D. Rooney¹, Charles S. Springer, Jr. ¹

Simulations based on Gradient Recalled Echo (GRE) data acquisition and a three site water exchange model for pharmacokinetic interpretation are used to investigate parameter influence in DCE-MRI analyses. It is shown that the speed of contrast reagent (CR) extravasation plays the most important role in determining the nature and degree of parameter influence, while the MRI pulse sequence parameter values also have an effect.