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Abstract #3397

High-Resolution DTI of Human Articular Cartilage with Long Diffusion Time: Preliminary Findings

Xu Feng1, Carol Muehleman2, Richard Magin1

1Bioengineering, University of Illinois at Chicago, Chicago, IL, United States; 2Biochemistry, Rush Medical College, Chicago, IL, United States

Recent publications have shown FA can reflect the orientation of the collagen fibers using DTI in MRI. However, the FA contrasts were low especially between the superficial and middle zone in those literatures. This was possibly because they selected the short diffusion time (δ < 10 ms). In our study, we increase the diffusion time from 10 ms to 30 ms so that the FA contrast increased by 4 times. We also suggest using the maximum diffusivity as a marker of hydration or PG loss of cartilage due to the less effect of the restricted diffusion.