Molly Gallogly Bright1,2, Manus J. Donahue2,
Daniel P. Bulte2, Jeff H. Duyn1, Peter Jezzard2
1Advanced MRI Section, LFMI, NINDS,
NIH, Bethesda, MD, United States; 2FMRIB Centre, Department of
Clinical Neurology, University of Oxford, Oxford, United Kingdom
Inflow
vascular space occupancy (iVASO) MRI uses arterial spin nulling and dynamic
subtraction to create cerebral blood volume (CBV)-weighted images that can be
sensitized to pre-capillary vessels. We aim to validate this technique by
examining the relationship between the iVASO contrast and graded levels of
CO2 inhalation, a common vasodilatory stimulus, in the human visual cortex.
Robust correlation between the iVASO measurements and end-tidal CO2 was
observed, indicating potential for iVASO techniques to improve our
understanding of the role of arterial CBV in regulatory vasoreactivity and
cerebrovascular disease.