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Abstract #3419

The Effect of Graded Hypercapnia on Arterial Cerebral Blood Volume (ACBV)-Weighted Inflow Vascular-Space Occupancy (IVASO) Contrast

Molly Gallogly Bright1,2, Manus J. Donahue2, Daniel P. Bulte2, Jeff H. Duyn1, Peter Jezzard2

1Advanced MRI Section, LFMI, NINDS, NIH, Bethesda, MD, United States; 2FMRIB Centre, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Inflow vascular space occupancy (iVASO) MRI uses arterial spin nulling and dynamic subtraction to create cerebral blood volume (CBV)-weighted images that can be sensitized to pre-capillary vessels. We aim to validate this technique by examining the relationship between the iVASO contrast and graded levels of CO2 inhalation, a common vasodilatory stimulus, in the human visual cortex. Robust correlation between the iVASO measurements and end-tidal CO2 was observed, indicating potential for iVASO techniques to improve our understanding of the role of arterial CBV in regulatory vasoreactivity and cerebrovascular disease.