Caffeine Reduces Resting-State BOLD Functional Connectivity

Wen-Chau Wu¹

We investigated the effect of caffeine upon resting-state BOLD connectivity by performing measurements at different anatomic areas (primary motor cortex, primary visual cortex, and thalamus) in combination with multiple TE's. Results showed that the obtained connectivity was more significant when data was collected with a longer TE, and noticeably dropped after caffeine injestion. When correlated to resting-state perfusion as measured by the pseudo-continuous arterial spin-labeling technique, the decrease of connectivity was larger in the region where caffeine caused more flow reduction, which suggested the role of vascular regulation in the functional connectivity measured by BOLD.