Valerie Griffeth1,2, Richard Buxton3
1Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States; 2Medical Scientist Training Program, University of California, San Diego, La Jolla, CA, United States; 3Department of Radiology, University of California, San Diego, La Jolla, CA, United States
We applied a calibrated-BOLD methodology to assess effects of caffeine consumption on coupling of CBF and cerebral metabolic rate of O2 (CMRO2) responses to a visual stimulus. Although the BOLD responses were similar, we found an increase in *** CMRO2 change after administration of caffeine, both as a fraction of the current baseline state and in a more absolute sense referred to the pre-caffeine baseline. More modest changes were found in the CBF response, leading to a decrease of the CBF/CMRO2 coupling ratio.