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Abstract #3476

A New Method for Measuring Changes in Venous Cerebral Blood Volume Using Hyperoxia

Nicholas P. Blockley1, Ian D. Driver1, Susan T. Francis1, Penny A. Gowland1

1Sir Peter Mansfield Magnetic Resonance Centre, School of Physics & Astronomy, University of Nottingham, Nottingham, United Kingdom

Venous cerebral blood volume (CBVv) is key to the BOLD response, but could not be measured directly until the advent of the VERVE technique. We present a new method for measuring changes in CBVv using hyperoxia. This new method has a high signal-to-noise ratio enabling high spatial (223mm) and temporal (TR=2.4s) resolution. In this work we show measurements of relative changes in CBVv. However with refinements to the acquisition and analysis it will be possible to measure the percentage change in CBVv.