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Abstract #3477

Spatial and Temporal Responses of Arterial and Venous Blood Volume Changes

Tae Kim1, Seong-Gi Kim1

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States

Spatial and temporal responses in arterial (CBVa) and total blood volume (CBVt) were measured in the same animals. Cortical depth profile analysis of ΔCBVa and ΔCBVt was performed to examine spatial specificity. The highest signal changes were detected at the middle of cortex in both ΔCBVa and ΔCBVa, and spatial specificity to the middle of the cortex appears to improve with time for both parameters. The venous blood volume response (ΔCBVv) was calculated by subtracting ΔCBVa from ΔCBVt. Rapid initial increases were obtained for CBVa, while slow prolonged increases were observed for CBVv.