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Abstract #3488

Resting State BOLD Fluctuations in Large Draining Veins Are Highly Correlated with the Global Mean Signal

Hongjian He1,2, David D. Shin2, Thomas T. Liu2

1Physics Department, Zhejiang University, Hangzhou, Zhejiang, China; 2Center for functional MRI, UC San Diego, La Jolla, CA, United States

Removal of the global mean signal is a common step in the processing of resting-state fMRI data. However, its usage can produce spurious negative correlations. . Here we propose the use of BOLD signal fluctuations in the large draining veins as an alternative to the global mean signal that does not force the existence of negative correlations. We show that signals from two vein regions (sagittal sinus and great vein of Galen) are significantly correlated with the global mean signal and may therefore represent a useful alternative for the analysis of resting-state fMRI studies.