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Abstract #3505

The Effects of Task Context and Brain Injury on Default Mode Network Brain Functional Connectivity

Suzanne T. Witt1, Vince D. Calhoun2,3, Godfrey D. Pearlson1,4, Michael C. Stevens1,4

1Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, United States; 2The MIND Institute, Albuquerque, NM, United States; 3Department of ECE, University of New Mexico, Albuquerque, NM, United States; 4Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States

Activity in the default mode network has been demonstrated to be correlated with rest and anti-correlated with task performance. Questions arising from this include whether task performance or brain abnormality, injury, or disease state modulate the default mode network. We show that both performance of an auditory oddball task as well as traumatic brain injury modulate the function of the default mode network. Performance of the task results in recruitment of additional frontal regions, while the presence of TBI alters the functional connectivity.