Suzanne T. Witt1, Vince D. Calhoun2,3,
Godfrey D. Pearlson1,4, Michael C. Stevens1,4
1Olin Neuropsychiatry Research Center,
Institute of Living, Hartford, CT, United States; 2The MIND
Institute, Albuquerque, NM, United States; 3Department of ECE,
University of New Mexico, Albuquerque, NM, United States; 4Department
of Psychiatry, Yale University School of Medicine, New Haven, CT, United
States
Activity
in the default mode network has been demonstrated to be correlated with rest
and anti-correlated with task performance.
Questions arising from this include whether task performance or brain
abnormality, injury, or disease state modulate the default mode network. We show that both performance of an
auditory oddball task as well as traumatic brain injury modulate the function
of the default mode network.
Performance of the task results in recruitment of additional frontal
regions, while the presence of TBI alters the functional connectivity.
Keywords