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Abstract #3506

DMN Is Affected Incongruently by Either Internal or External Environments

Tun Jao1,2, Ya-Chih Yu1, I-Ning Tang1, Chang-Wei Wu1, Jiann-Shing Jeng3, Jyh-Horng Chen1

1MRI/MRS Lab, NTU, Taiwan, Taipei, Taiwan; 2Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; 3National Taiwan University Hospital, Stroke Center and Department of Neurology, Taipei, Taiwan

In this study, we deprive subjects from light and aim to investigate possible fluctuations of DMN under visual deprivation. 10 healthy subjects underwent 4 resting-state scans: 1) eyes-closed in dark, 2) eyes-open in dark, 3) eyes-closed in light, and 4) eyes-open in light. PCC was chose as the seed to generate PCC-FC map. FC between PCC and PCu, thalamus, and prefrontal cortex fluctuated significantly but incongruently. Besides the effect of physiological conditions, DMN also showed changes upon light. To sum up, DMN fluctuates incongruently across different situations. Both intrinsic physiological activities and external environments contribute to these changes.