Abstract #3508

Spontaneous Low-Frequency BOLD Signal Fluctuations: Changes in Default Mode Network in Brain Diseased with Glioblastoma

Heisoog Kim^1,2, Alexander E. Drzezga¹, Ciprian Catana¹, Grace Kim¹, Ovidiu C. Andronesi¹, Dominique L. Jennings¹, Elizabeth R. Gerstner³, Tracy T. Batchelor³, Rakesh K. Jain⁴, Alma Gregory Sorensen¹

¹A.A.Martinos center, Massachusetts General Hospotal, Charlestown, MA, United States; ²NSE/HST, Massachusetts Institute of Technology, Cambridge, MA, United States; ³Neurology, Massachusetts General Hospotal, Boston, MA, United States; ⁴Radiology, Massachusetts Institute of Technology, Boston, MA, United States

This pilot study investigated quantitative changes in the default mode network (DMN) in patients with glioblastoma (GB) to understand how brain tumors and their associated treatment affect the integrity of the DMN. In general, it was possible to identify coherent BOLD DMN-activity in brain tumor patients in a similar pattern as demonstrated previously in healthy subjects. However, distinct asymmetry of the DMN was observed with a decreased connectivity of the inferior parietal cortex in tumor-affected hemisphere. The z-score values were reduced in a hemisphere diseased with GB compared to those in a contralateral hemisphere.