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Abstract #3509

Acute Social Stress Increases Amygdala Functional Connectivity with Posterior Cingulate Cortex and Medial Orbitofrontal Cortex

Ilya Milos Veer1,2, Nicole Y. Oei1,3, Mark A. van Buchem1,2, Bernet M. Elzinga1,3, Serge A. Rombouts1,2

1Leiden Institute for Brain and Cognition (LIBC), Leiden, Netherlands; 2Department of Radiology, Leiden University Medical Center (LUMC), Leiden, Netherlands; 3Leiden University - Institute of Psychology, Leiden, Netherlands

The amygdalae are crucial in mediating stress effects and have extensive interplay with brain regions involved in emotion and memory. The present study investigated whether acute stress alters amygdala functional connectivity with these areas. Healthy males underwent acute social stress (n=18) or a control procedure (n=20). Hereafter, resting-state fMRI data were acquired. Group differences were analyzed in a priori regions of interest (p≤0.001, uncorrected). After stress, increased amygdala connectivity with the posterior cingulate cortex and medial orbitofrontal cortex was found. Acute social stress thus has prolonged effects on amygdala functional connectivity with areas involved in emotion processing and regulation.