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Abstract #3511

A Comprehensive Study of Whole-Brain Functional Connectivity and Grey Matter Volume in Children and Young Adults

Dietsje D. Jolles1,2, Mark A. Van Buchem2,3, Eveline A. Crone, 3,4, Serge A. Rombouts, 23

1Leiden Institute for Brain and Cognition (LIBC), Leiden , Netherlands; 2Department of Radiology, Leiden University Medical Centre, Leiden, Netherlands; 3Leiden Institute for Brain and Cognition (LIBC), Leiden, Netherlands; 4Developmental and Educational Psychology, Leiden University, Leiden, Netherlands

In the present study we investigated voxel-wise whole-brain functional connectivity in children (11-13 years) and adults (19-25 years), without a priori restriction to specific seed regions or networks. In addition we examined to what extent observed changes in functional brain connectivity could be explained by changes in local grey matter. We show that networks in children were more widespread than adult networks. Moreover, several networks showed altered connectivity in children compared to adults. The majority of the observed changes in functional connectivity could not be explained by changes in grey matter volume.