Thalia
Van der Doef1,2, Fernando Osmin Zelaya2, Sarah Lee2,
Astrid Pauls2,3, Mitul Mehta2
1VU University Medical Centre, VU
University, Amsterdam, Netherlands; 2Centre for Neuroimaging
Sciences, Institute of Psychiatry, London, United Kingdom; 3VU
University, Netherlands
A
modified breath-hold (BH) paradigm was used to assess the effect of
methylphenidate administration on the BH response function. An oral dose of 40mg of methylphenidate or
a placebo were randomly administered to a group of 16 male subjects who took
part in two separate scans one week apart. Whilst no statistically
significant effect was found on the averaged temporal signal of grey matter,
a significant increase in the amplitude of the BH response in the
frontal-superior medial cortex (FSMC) was observed; as well as a significant
reduction in latency in the putamen, the caudate nucleus and the FSMC
Keywords