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Abstract #3521

Cerebellar Abnormalities in Adolescents with Marijuana Dependence

Melissa Lopez-Larson1,2, Jadwiga Rogowska3, Deborah Yurgelun-Todd1,2

1Brain Institute, University of Utah, Salt Lake City, UT, United States; 2VISN 19 MIRECC, Salt Lake City, UT, United States; 3Brain Imaging Center, McLean Hospital/Harvard Medical School, Belmont, MA, United States

This is one of the first studies to evaluate cortico-cerebellar circuits in a group of adolescents with heavy marijuana (MJ) use utilizing a bilateral finger tapping fMRI task. Nineteen MJ using adolescents and 19 aged-matched healthy controls (HC) had functional (f)MRI scans on a 3T Siemens Trio scanner, including a standard bilateral fMRI finger tapping sequence. HC were found to have greater activation than MJ for Broadmanns areas 4 and 6 and in the cerebellum. Furthermore, our findings suggest that age of first use and amount of MJ used may have an impact on functioning in the developing brain.