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Abstract #3544

Thalamo-Cortical Responses to Deep Brain Stimulation of the Posterior Hypothalamic Nucleus in Rats-An FMRI Study of Neuroconnectivity

Jeff F. Dunn1,2, Calvin K. Young1,3, Ursula I. Tuor1,4, Campbell Teskey1,5, Brian H. Bland1,3

1Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; 2Department of Radiology, University of Calgary, Calgary, Alberta, Canada; 3Department of Psychology, University of Calgary; 4NRC Institute of Biodiagnostics, University of Calgary; 5Departments of Cell Biology and Anatomy/ Psychology, University of Calgary

Deep brain stimulation has been successful at treating Parkinsons disease and has potential for treating other disorders. Neuroconnectivity between regions is important in understanding functional outcome. We stimulated within the posterior hypothalamic nuclei in a rat model (which has been shown to reduce haloperidol and 6-OHDA lesion induced akinesia). We used a novel implantable electrode suitable for use at 9.4T. fMRI responses in the cortex and other regions were monitored. Large regions of the cortex (bilateral) and hippocampus show a positive BOLD response. This extensive neuroconnectivity helps explain the positive response to DBS in the posterior hypothalamic nuclei.