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Abstract #3559

Measurement of Changes in Left Ventricular Volume and Strain During Isovolumic Relaxation

June Cheng-Baron1, Kelvin Chow1, Ben T. Esch2, Jessica M. Scott2, Mark J. Haykowsky2, John V. Tyberg3, Richard B. Thompson1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada; 2Physical Therapy, University of Alberta, Edmonton, AB, Canada; 3Cardiac Sciences, University of Calgary, Calgary, AB, Canada

Left ventricular (LV) volume estimated using ventricular dimensions or surface markers have shown increasing volume during isovolumic relaxation, despite closed mitral and aortic valves. The goal of this study is to explain and interpret this volume increase in the context of ventricular relaxation. We measure a 4.6 mL mean increase in LV volume, which is correlated with changes in principle myocardial strains and compensated for by the descent of the mitral leaflets towards the apex. The motion of the leaflets and conformational changes in the LV during isovolumic relaxation likely reflect LV pressure decline and the development of ventricular suction.