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Abstract #3568

Transplantation of Murine Embryonic Stem Cell-Derived Cardiomyocytes Improves Cardiac Function in the Infarcted Heart

HuaLei Zhang1, Hui Qiao1, Nataliya Petrenko2, Vickas Patel2, Bin Huang3, Kenneth Boheler4, Victor Ferrari2, Rong Zhou1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Dept of Medicine(cardiovascular), University of Pennsylvania; 3Department of Radiology, University of Pennsylvania, PA; 4National Institute of Aging, NIH

Highly enriched embryonic stem cell derived cardiomyocytes (ESC-CMs) were obtained in large numbers for in vivo study that examined the potential of these cells in the treatment of myocardial infarction. Our data suggest that ESC-CM mediated a teratoma free myocardial repair with significant recovery of regional and global contractile function over the period of 2 months.