Yong Chen1,2, Julian E. Stelzer3,
Xin Yu1,2
1Department of Biomedical Engineering,
Case Western Reserve University, Cleveland, OH, United States; 2Case
Center for Imaging Research, Case Western Reserve University, Cleveland, OH,
United States; 3Department of Physiology and Biophysics, Case
Western Reserve University
In
the present study, we evaluated the impact of shift in myosin heavy chain
(MHC) isoforms on in vivo ventricular function in thyroid-deficient rats. Our
results show that increased expression of β-MHC not only reduced the
magnitude of peak systolic strain and torsion, but also altered the timing
when the myocardium reached peak systole, leading to deteriorated cardiac
function in hypothyroid rat hearts.