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Abstract #3576

Increased Left Ventricular Torsion in Hypertrophic Cardiomyopathy Mutation Carriers with Normal Wall Thickness

Iris Rssel1, Wessel Brouwer1, Tjeerd Germans1, Paul Knaapen1, J Tim Marcus1, Jolanda van der Velden1, Marco Gtte1, Albert van Rossum1

1VU University Medical Center, Amsterdam, Netherlands

Hypertrophic cardiomyopathy (HCM) is caused by mutations in mainly sarcomeric genes. Increased left ventricular (LV) torsion has been observed in patients with manifest hypertrophy, but abnormalities in myocardial contractility might already be present in HCM mutation carriers with normal wall thickness. Therefore, LV torsion and endocardial circumferential strain were studied in HCM mutation carriers using MRI tagging. Increased LV torsion and torsion to endocardial circumferential strain-ratio were found in carriers with respect to controls. The observed difference might be due to HCM-related endocardial myocardial dysfunction.