Abstract #3586

Assessment of Cardiac Function and Infarct Size Following Myocardial Infarction in Mitochondrial Cyclophilin-D Knockout Mice

Anthony N. Price¹, Shiang Y. Lim², Johannes Riegler¹, Derek M. Yellon², Derek J. Hausenloy², Mark F. Lythgoe¹

¹Centre for Advanced Biomedical Imaging, Department of Medicine and UCL Institute of Child Health, University College London, London, United Kingdom; ²The Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom

Coronary heart disease (CHD) remains one of the leading causes of morbidity and mortality worldwide. A principal symptom of CHD is myocardial infarction (MI), which leads to a complex process of ventricular remodelling and ultimately heart failure. Novel treatment strategies which are capable of limiting myocardial infarct size, preventing LV remodelling and preserving cardiac function are needed to improve clinical outcomes. The inhibition of mitochondrial cyclophilin-D (CypD), has been reported to reduce infarct size in pre-clinical studies. Here we present the first MRI assessment of cardiac function and infarct size in CypD^-/- mice at 48 hours following myocardial infarction.