Kieren Grant Hollingsworth1, David Emerys
Jones2, Julia Lindsay Newton3, Bernard D. Keavney4,
Guy A. MacGowan5, Andrew Mark Blamire1
1Newcastle Magnetic Resonance Centre,
Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 2Institute
of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and
Wear, United Kingdom; 3Institute for Ageing and Health, Newcastle
University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 4Institute
of Human Genetics, Newcastle University, Newcastle upon Tyne, Tyne and Wear,
United Kingdom; 5Cardiology, Freeman Hospital, Newcastle upon
Tyne, Tyne and Wear, United Kingdom
It
is unclear whether there are relationships between cardiac energetics and
age-related decline of systolic and diastolic function. 25 healthy females
with no previous history of cardiac disease were recruited, covering the age
range 18-65. Phosphorus spectroscopy, cine imaging and cardiac tagging were
carried out. PCr/ATP ratio was found to decline significantly with age, most
strongly in the over 60 group. E/A ratio, peak circumferential strain and
torsion recoil rates declined with age, with the first two significantly
associated with the PCr/ATP ratio. This suggests that both systolic and
diastolic function are associated with energetic changes in ageing.
Keywords