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Abstract #3588

γ-Sarcoglycan Deficiency Reduces Cardiac Function and T2 in Old Mice

Sean Charles Forbes1, Sean Germain2, Nathan Bryant3, Glenn A. Walter3

1Department of Physical Therapy, University of Florida, Gainesville, FL, United States; 2Department of Pediatrics, University of Florida, United States; 3Department of Physiology and Functional Genomics, University of Florida, United States

Limb Girdle muscular dystrophy Type 2C is characterized by a deficiency in γ-sarcoglycan, a protein associated with the dystrophin-glycoprotein complex on the cell membrane. In this study, the effects of a lack of γ-sarcoglycan (Sgsg-/-) and dystrophin (mdx) on cardiac function and myocardium T2 in old mice were examined. The findings indicate that Sgsg-/- and mdx have a reduced left ventricular ejection fraction compared to age-matched controls, with no differences in Sgsg-/- and mdx. Also, a shorter T2 was observed in the myocardium of Sgsg-/- compared to controls, suggesting an increased prevalence of fibrosis in Sgsg-/-.