Aleksandra Radjenovic1, John D. Biglands1, Abdulghani Larghat1, John P. Ridgway1, Michael Jerosch-Herold2, John P. Greenwood1, Sven Plein1
1School of Medicine, University of Leeds, Leeds, England, United Kingdom; 2Brigham and Womens Hospital, Harvard Medical School, Boston, MA, United States
Dynamic contrast-enhanced MRI was performed in 17 volunteers to simultaneously assess systolic and diastolic myocardial blood flow (MBF). At rest transmural MBF estimates were similar in systole and diastole (1.6 0.42 vs 1.7 0.49 ml/g/min, p>0.05). During adenosine-induced hyperaemia, MBF was significantly lower in systole than diastole (4.3 0.93 vs 5.7 1.7 ml/g/min, p < 0.0001). Subendocardial MBF was higher than subepicaridal MBF, apart from systole at stress where this relation was reversed. In conclusion, estimates of hyperaemic MBF differ significantly between systole and diastole, following the expected physiological pattern of preferential diastolic filling.