From Men to Mice: Theoretical Considerations for Edema Imaging at Ultra-High Magnetic Fields

Jurgen E. Schneider¹, Steffen Bohl¹, Erica Dall'Armellina¹, Stefan K. Piechnik¹, Matthew D. Robson¹, Stefan Neubauer¹

T2-weighted magnetic resonance imaging (T2w-MRI) has been shown to visualize and to quantify edema in the acutely infarcted myocardium of humans and animal models. Based on relaxation time measurements, we quantitatively demonstrate that the achievable T2-contrast between normal and ischemia-reperfusion injured myocardium in mice at 9.4T is only 60% of the contrast in patients with acute myocardial infarction undergoing CMR at 3T.