Abstract #3634

MR Tagging on Healthy and MI Mice Model, an EF Vs Strain Study

Andrea Protti¹, Alexander Sirker¹, Ajay M. Shah¹, Rene Botnar²

¹Cardiovascular Division, Kings College London BHF Centre of Excellence, London, United Kingdom; ²Division of Imaging Sciences, Kings College London BHF Centre of Excellence, London, United Kingdom

In this study we sought to investigate radial and circumferential strain in a mouse model of myocardial infarction (MI) 3 weeks post left anterior diagonal (LAD) coronary artery ligation and healthy control mice using 2D SPAMM technique. Strain was correlated with ejection fraction (EF) and left ventricular (LV) infarct size. MR tagging analysis provided important information on LV regional contraction and allowed assessment of wall motion alterations in MI mice.